Science and Technology Development Journal 2019-01-17T22:51:22+00:00 Phuc Van Pham Open Journal Systems In vitro α-glucosidase inhibitory activity of compounds isolated from mangrove Lumnitzera littorea leaves 2019-01-17T22:51:22+00:00 Thuy Thi Le Nguyen Thuy Thi Pham Poul Erik Hansen Phung Kim Phi Nguyen <p><strong>Introduction</strong>: Lumnitzera littorea grown at CanGio Mangrove Forest has been investigated. The present study reports the isolation, characterization and evaluation of the alpha-glucosidase inhibitory activity of isolated compounds from Lumnitzera littorea leaves.</p> <p><strong>Methods</strong>: Their structures were elucidated by spectroscopic methods (including MS, 1D and 2D–NMR) and comparison with values from the literature. From the n-hexane extract, nine compounds including lupeol (<strong>1</strong>), betulin (<strong>2</strong>), betulinic acid (<strong>3</strong>), oleanolic acid (<strong>4</strong>), corosolic acid (<strong>5</strong>), -sitosterol (<strong>6</strong>), beta-sitosterol 3-O- beta-D-glucopyranoside (<strong>7</strong>), stigmast-5-ene-3beta-O-(6-O-hexadecanoyl-beta-D-glucopyranoside) (<strong>8</strong>), and stigmast-4-ene-3-one (<strong>9</strong>) were isolated and identified.</p> <p><strong>Results</strong>: The results of the alpha-glucosidase inhibitory activity showed thatcorosolic acid (5) and oleanolic acid (4) were the most potent, with IC<sub>50</sub> values of 17.86 +/- 0.42 and 18.82 +/- 0.59 ug/mL, respectively. Five of the other seven compounds exhibited inhibitory activity with IC<sub>50</sub> values below 100 ug/mL, and higher than the positive control acarbose (127.64 +/- 0.64 ug/mL).</p> <p>&nbsp;</p> 2019-01-07T13:39:57+00:00 ##submission.copyrightStatement##