Science and Technology Development Journal 2021-09-21T23:17:32+00:00 Phuc Van Pham Open Journal Systems Phenolic compounds from the lichen Parmotrema cristiferum (Taylor) Hale 2021-09-21T23:17:32+00:00 Nguyen Thi Ngoc Van Nguyen Mong Anh Nguyet Tran Thai Bao Nguyen Thi Le Thuy Bui Thanh Tung Pham Nguyen Kim Tuyen Nguyen Thi Hoai Thu Nguyen Thi Anh Tuyet Huynh Bui Linh Chi Nguyen Kim Phi Phung Ngo Thi Thuy Duong <p><strong>Introduction</strong>: Lichens are fungal and algal or cyanobacterial symbioses resulting in the production of specific metabolites with a great variety of effects such as antimycobacterial, antiviral, antiinflammatory, antipyretic and antiproliferative. Parmotrema cristiferum (Taylor) Hale, a species of foliose lichen, was collected at Champasack Province, Laos in April 2015. This paper describes the isolation and structure elucidation of nine compounds isolated from this lichen.</p> <p><strong>Methods</strong>: Phytochemical investigations of the chloroform extract of the lichen P. cristiferum led to the isolation of nine pure compounds. Their chemical structures were elucidated by extensive HR-ESI-MS and 1D and 2D-NMR spectroscopic analysis, and comparison with previously published data.</p> <p><strong>Results</strong>: From the studied lichen, nine compounds, orcinol (<strong>1</strong>), orsellinic acid (<strong>2</strong>), atranol (<strong>3</strong>), methyl beta - orsellinate (<strong>4</strong>), atranorin (<strong>5</strong>), diffractaic acid (<strong>6</strong>), lecanoric acid (<strong>7</strong>), bailesidone (<strong>8</strong>), and tinctorinone (<strong>9</strong>) were isolated, structurally elucidated and evaluated for their a-glucosidase inhibitory activity.</p> <p><strong>Conclusions</strong>: Among isolated compounds, except 2, 4, and 7, the remaining six compounds were known for the first time from the lichen P. cristiferum. All these compounds were inactive in the a-glucosidase enzyme inhibitory assay.</p> 2021-09-21T00:00:00+00:00 ##submission.copyrightStatement##