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VNUHCM Journal of

Science and Technology Development

An official journal of Viet Nam National University Ho Chi Minh City, Viet Nam since 1997

ISSN: 1859-0128
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Biological test against breast adenocarcinoma cells (MCF-7) of acylated products of 3-methyl-4 thiorhodanine

Giau Hoang Le 1, *
Nha To Nguyen 1
Duong Thi Thuy Ngo 1
Quang That Ton 1
Phung Thi Kim Nguyen 1
Tuyen Nguyen Kim Pham 2
Fritz Duus 3

  1. University of Science, VNU-HCM
  2. Sai Gon University
  3. Roskilde University, Denmark
Correspondence to: Giau Hoang Le, University of Science, VNU-HCM. Email: pvphuc@vnuhcm.edu.vn.
Volume & Issue: Vol. 18 No. 1 (2015) | Page No.: 63-69 | DOI: 10.32508/stdj.v18i1.1035
Published: 2015-03-31

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Copyright © 2015 by the author(s).

Copyright The Author(s) 2023. This article is published with open access by Vietnam National University, Ho Chi Minh city, Vietnam. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. 

Abstract

Rhodanine and its derivatives are not only valued for their interesting chemical properties but also present a wide range of bioactivities and their chemical and pharmacological applications have been investigated. From 3-methyl-4-thiorhodanine we synthesized S-acylated and C-acylated products using (some) carboxylic acid chlorides and the obtained products were studied the anti-proliferative activity by a SRB (sulforhodamine B) assay against a human breast cancer cell line. The results showed that C-acylated products are better inhibitors than S-acylated products.

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