Abstract

Objectives: This study aims to explore global research trends in pharmacoeconomics over the past decade through a bibliometric analysis of publications from 2015 to 2024. Methods: A bibliomet-ric analysis of pharmacoeconomic research articles published between 2015 and 2024, sourced from the PubMed database, was conducted using a structured search strategy targeting economic evaluation terms in combination with drug-related keywords. Data were analyzed using the Bib-lioshiny interface of the bibliometrix R package to assess publication trends, journal and institutional productivity, international collaboration, and thematic evolution. Citation data were further en-riched using metadata retrieved via the CrossRef REST API utilizing the httr, jsonlite, dplyr, and purrr packages in R. Results: The most prolific journals included Journal of Medical Economics , Pharma-coeconomics, andPLOS ONE. Foundational concepts such as ''cost-effectiveness analysis'' and ''sys-tematic review'' remained dominant throughout the decade. Since 2020, disease-specific terms like ''type diabetes'', ''chronic hepatitis'', ''lung cancer'', and ''urothelial carcinoma'' gained promi-nence, reflecting increasing interest in evaluating interventions for high-burden diseases. When considering all-author affiliations, China had the highest number of publications. However, when limited to corresponding authors, typically indicating research leadership, the United States and the United Kingdom led in output and citation impact. Conclusion: This bibliometric review highlights significant trends in pharmacoeconomics research over the last decade. There is a growing empha-sis on evaluating therapies for infectious and chronic diseases, with strong contributions from US-and UK-based institutions. These findings can guide future research priorities, funding allocation,and collaborative strategies in global health economics.