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VNUHCM Journal of

Science and Technology Development

An official journal of Viet Nam National University Ho Chi Minh City, Viet Nam since 1997

ISSN: 1859-0128
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ALPHA-GLUCOSIDASE INHIBITORY LIMONOIDS FROM THE LEAVES OF AZADIRACHTA INDICA A. JUSS GROWN IN NINH THUAN PROVINCE

Nhi Thi Y Nguyen 1, *
Qui Kim Tran 1
Quan Le Tran 1

  1. University of Science, VNU-HCM
Correspondence to: Nhi Thi Y Nguyen, University of Science, VNU-HCM. Email: pvphuc@hcmuns.edu.vn.
Volume & Issue: Vol. 14 No. 2 (2011) | Page No.: 36-42 | DOI: 10.32508/stdj.v14i2.1941
Published: 2011-06-30

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Copyright © 2011 by the author(s).

Copyright The Author(s) 2023. This article is published with open access by Vietnam National University, Ho Chi Minh city, Vietnam. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. 

Abstract

Two new limonoids, named nimbandiol A (1) and azadirachtolid E (2) were isolated from the leaves of Azadirachta indica, along with deoxyazadirachtolid (3), a known compound. Their structures were determined by spectroscopic methods and compared with literatures. Three compounds (1-3) showed moderate a-glucosidase inhibitory activities against Saccharomyces cerevisiae a-glucosidase with IC50 values of 38.7 mM, 85.76 mM and 48.24 mM, respectively.

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