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Abstract
Carbohydrates have gained much attention as cheap chiral starting materials in stereocontrolled target oriented synthesis. β-lactam antibiotics still remain the main tool against bacterial infections but the search for new active compounds has not been the aim of reported investigations. Synthesis of β-lactam antibiotics from carbohydrate precursors played a special role owing to the importance of these classes of compounds in modern chemotherapy. In this report, we carried out this subject to synthesize β-lactam derivative (oxacepham) via [2 + 2] cycloaddition of chlorosulfonyl isocyanate (CSI) to vinyl ether derived from carbohydrate (α-D-glucose).
Issue: Vol 18 No 3 (2015)
Page No.: 87-95
Published: Aug 30, 2015
Section: Engineering and Technology - Research article
DOI: https://doi.org/10.32508/stdj.v18i3.877
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