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VNUHCM Journal of

Science and Technology Development

An official journal of Viet Nam National University Ho Chi Minh City, Viet Nam since 1997

ISSN: 1859-0128
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Preparation of cefuroxime from 7-ACA

Tan Khanh Nguyen 1, *
Nhuan Ngoc Doan 1
Tinh Van Dang 2

  1. VNUHCM-University of Science
  2. University of Medicine and Pharmacy, Ho Chi Minh City
Correspondence to: Tan Khanh Nguyen, VNUHCM-University of Science. Email: pvphuc@vnuhcm.edu.vn.
Volume & Issue: Vol. 18 No. 4 (2015) | Page No.: 111-116 | DOI: 10.32508/stdj.v18i4.914
Published: 2015-12-30

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Copyright © 2015 by the author(s).

Copyright The Author(s) 2023. This article is published with open access by Vietnam National University, Ho Chi Minh city, Vietnam. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. 

Abstract

Cefuroxime, a second generation cephalosporin antibiotic, is synthesized from starting materials 7-ACA (7-amino cephalosporinic acid) and SMIA (2-furanyl- (Z)-2-methoxyiminoacetic acid ammonium salt). The study showed that the product could be prepared via a 4 step scheme to obtain cefuroxime in good total yield of 42 %.

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