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VNUHCM Journal of

Science and Technology Development

An official journal of Viet Nam National University Ho Chi Minh City, Viet Nam since 1997

ISSN: 1859-0128
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Preparation of bio - adhesive hydrogel based on chitosan for wound sealant

Diem Thi My Pham 1, *
Hoa Thi Hoang 2
Vu Dinh Dang 3
Quyen Ngoc Tran 4

  1. Lac Hong University
  2. Ton Duc Thang University
  3. Can Tho University
  4. Institute of Applied Materials Science, Ho Chi Minh
Correspondence to: Diem Thi My Pham, Lac Hong University. Email: pvphuc@vnuhcm.edu.vn.
Volume & Issue: Vol. 18 No. 2 (2015) | Page No.: 88-95 | DOI: 10.32508/stdj.v18i2.1136
Published: 2015-06-30

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Copyright © 2015 by the author(s).

Copyright The Author(s) 2023. This article is published with open access by Vietnam National University, Ho Chi Minh city, Vietnam. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. 

Abstract

In this study, we introduce a new kind of hydrogel based on oxidized chitosan for tissue adhesion. The hydrogel formed rapidly in a few seconds in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The in vitro cytocompatible experiment with fibroblast cell using kit live/dead assay showed that the hydrogel was highly biocompatible. Evaluation of tissue adhesion performed on pork skin the maximum tissue adhesive forces are 88 kPa for chitosan hydrogel and 105 kPa for oxidized chitosan hydrogel.. These results suggest that chitosan hydrogel possessed the wound healing ability and promises a tissue adhesive devices for biomedical applications.

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