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Abstract

The purpose of this study is to i) fabricate a biodegradable nanoparticle formulation of Ketoprofen, ii) evaluate its characteristics, iii) investigate its in vitro dissolution and in vivo pharmaceutical property. The nanoparticle formulation was prepared by spray drying method using Eudragit L100 as the matrix polymer. Size and morphology of drug-loaded nanoparticles were characterized with the electron microscopes (TEM, SEM). These successfully prepared nanoparticles by spray drying method are spherical in shape and quite homologous with diameter size of 100 – 200 nm. The in vitro dissolution studies were conducted at pH 1.2 and 7.4. The results indicated that there is a significant increase in Keto concentration at pH 7.4 compared to pH 1.2. For the in vivo assessment, our Keto-loaded nanoparticles and referential Profenid were administered by oral gavages to rabbits. The results implied that Keto-loadednanoparticles remarkably increased AUC compared to Profenid.



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Article Details

Issue: Vol 16 No 1 (2013)
Page No.: 15-25
Published: Mar 31, 2013
Section: Engineering and Technology - Research article
DOI: https://doi.org/10.32508/stdj.v16i1.1415

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Creative Commons License

Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Dao, T., Le, N., Nguyen, A., Tran, K., Le, D., Dang, C., & Nguyen, C. (2013). In vitro and in vivo evaluation of sustained release ketoprofen-loaded nanoparticles. Science and Technology Development Journal, 16(1), 15-25. https://doi.org/https://doi.org/10.32508/stdj.v16i1.1415

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