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Abstract

We investigated the relationship between anti-proliferative activity and apoptosis induction of plant-derived agents such as vinblastine, camptothecin, and plumbagin on HEp-2 cancer cell line. Analysis of cellular DNA content at different incubation time showed that vinblastine of 0.004 µg/ml caused cell-cycle arrest at G2/M phase after 26-hourincubation, camptothecin of 1 µg/ml and plumbagin of 10 µg/ml caused cell-cycle arrest at G0/G1 phase after 12-hour incubation. Flow cytometric analysis showed that after specific cell-cycle arrest phases, HEp-2 cells treated with vinblastine, camptothecin, and plumbagin went through apoptotic process. This process depends on drug concentration and incubation time.

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Issue: Vol 11 No 7 (2008)
Page No.: 5-10
Published: Jul 31, 2008
Section: Natural Sciences - Research article
DOI: https://doi.org/10.32508/stdj.v11i7.2656

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
To Trinh, T., Thuy Vy, N., Hoai Nghia, N., Thanh, L., Xuan Lien, T., & Thuy Duong, H. (2008). INVESTIGATION OF THE RELATIONSHIP BETWEEN ANTIPROLIFERATIVE ACTIVITY AND APOPTOSIS INDUCTION OF PLANTDERIVED AGENTS ON HEp-2 CANCER CELL LINE. Science and Technology Development Journal, 11(7), 5-10. https://doi.org/https://doi.org/10.32508/stdj.v11i7.2656


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