Abstract

Gossypol, a polyphenolic aldehyde from cottonseed oil, has at tracted much attention as a potential male antifertility drug. Selective toxicity of gossypol againts various cancer cell lines and experimental tumors has been demonstrated, suggesting its possible therapeutic use. More recently, a numbers of researchs indicated that the derivatives of the aldehydic functions of(...) gossy pol with twenty monoamines and polyamines were of biological and industrial interest. A series of peri-acylated gossypylic nitriles had also antiviral activities. The present report presents the synthesys of analogue of gossypol such as methyl ester of phenynlalanine-gossypol derivative, an attempt to find more effective and/or less toxic entities.