Solid dispersion system – An effective solution to enhance solubility of mangiferin

Abstract

Mangiferin - a xanthonoid abundantly present in Mango leaves has been widely recognized a potent hypoglycemic, antioxidant, and anti-inflammatory agent. Nevertheless, due to its poor solubility and poor permeability, its bioavailability and application in large scale remain limited. Amongst different methods for enhancement of such poor-soluble drugs, solide dispersion (SD) appears as a potent strategy, which is widely applied in pharmaceutical industry to enhance firstly dissolution rate and subsequently bioavalability of BCSII and BCSIV drugs. In this study, different solid dispersion (SD) systems of mangiferin with beta-cyclodextrin (β-CD), polyethylene glycol 6000 (PEG 6000), polyvinylpyrrolidone K30 (PVP K30), and hydroxypropyl methylcellulose (HPMC) 6M were prepared, using wet grinding and solvent evaporation methods, and compared in terms of mangiferin’s solubility. The results showed that the optimized SD of mangiferin and HPMC 6M (at 1:5 ratio), prepared by solvent evaporation method, achieved the highest dissolution rate of 81.96% after 30 minutes and 91.89% after 60 minutes at pH 1.2. Furthermore, differences in the material structure as well as the chemical composition between the optimized SD formula and raw Mangiferin were investigated and compared using the electronic microscopy (SEM), differential scanning calorimetry (DSC) and infra-red spectroscopy (IR). Overall, the findings within this study highlighted the potential of SD method in an attempt to enhance the solubility of active compounds in the class BCS II or BCS IV.