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VNUHCM Journal of

Science and Technology Development

An official journal of Viet Nam National University Ho Chi Minh City, Viet Nam since 1997

ISSN: 1859-0128
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Engineering and Technology - Research article Open Access Logo

Development of INCAT-GC-MS for analysis of metabolites in urine

Peter Podolec 1
Alexandra Hengerics Szabó 1
Viktória Ferenczy 2
Peter Kotora 2
Jaroslav Blaško 2
Róbert Kubinec 2
Stanislav Stuchlík 3
Martin Juriga 4
Radomír Čabala 5
Thanh Manh Ngo 6, *

  1. PríF UK, Šafárikovo námestie 6, 81499 Bratislava, Slovakia
  2. Chemický Ústav PríF UK, Mlynská dolina CH-2, 84215 Bratislava, Slovakia
  3. Katedra Molekulárnej Biologie PríF UK, Mlynská dolina CH-2, 84215 Bratislava, Slovakia
  4. Ústav Chemických a Hydraulických strojov a zariadení, SjF STU, Nám. Slobody 17, 81231 Bratislava, Slovakia
  5. Katedra Analytickej Chémie PríF UK, Albertov 6, 128 43 Praha 2, Czech Republic Ústav Súdnej Medicíny a Toxikologie, Univerzitná Nemocnica, U Nemocnice 2, 128 08 Praha 2, Czech Republic
  6. o Chi Minh city University of Technology, VNU-HCM, Vietnam
Correspondence to: Thanh Manh Ngo, o Chi Minh city University of Technology, VNU-HCM, Vietnam. Email: pvphuc@vnuhcm.edu.vn.
Volume & Issue: Vol. 19 No. 1 (2016) | Page No.: 106-113 | DOI: 10.32508/stdj.v19i1.615
Published: 2016-03-31

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Copyright © 2016 by the author(s).

Copyright The Author(s) 2023. This article is published with open access by Vietnam National University, Ho Chi Minh city, Vietnam. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. 

Abstract

This paper aims to develop a non-solvent microextraction technique using INCAT (Inside Needle Capillary Adsorption Trap) for GC-MS analysis of volatile metabolites in urine. INCATs with different sorbents were tested, resulting in an INCAT with 3 sorbent layers Chromosorb W+ 20% SE-54, Carbopack X and Carboxen 1000 (1 : 1 : 1), which proved to be the most suitable for differentiating and identifying volatile metabolites in urine samples of patients from those of healthy people.

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