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Abstract
Rhodanine and its derivatives are not only valued for their interesting chemical properties but also present a wide range of bioactivities and their chemical and pharmacological applications have been investigated. From 3-methyl-4-thiorhodanine we synthesized S-acylated and C-acylated products using (some) carboxylic acid chlorides and the obtained products were studied the anti-proliferative activity by a SRB (sulforhodamine B) assay against a human breast cancer cell line. The results showed that C-acylated products are better inhibitors than S-acylated products.
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Article Details
Issue: Vol 18 No 1 (2015)
Page No.: 63-69
Published: Mar 31, 2015
Section: Natural Sciences - Research article
DOI: https://doi.org/10.32508/stdj.v18i1.1035
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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
How to Cite
Le, G., Nguyen, N., Ngo, D., Ton, Q., Nguyen, P., Pham, T., & Duus, F. (2015). Biological test against breast adenocarcinoma cells (MCF-7) of acylated products of 3-methyl-4 thiorhodanine. Science and Technology Development Journal, 18(1), 63-69. https://doi.org/https://doi.org/10.32508/stdj.v18i1.1035
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