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Bone marrow failure (BMF) is a disease characterized by a drastic decline in the marrow's functional ability to produce blood cells. Emmanuel C Base et al (2008), the ratio of BMF disease in China, Asia is higher than Europe and US about from 3 to 4 fold. In Vietnam, the dangerous of BMF is ranked third among blood diseases (Vietnam Ministry of Health). Animal models of bone marrow failure syndromes have not only helped to strengthen our understanding of the mechanisms causing bone marrow failure but also applied for pre-clinical experiments. The aims of this research are: creating mouse (Mus musculus var Albino) models for bone marrow failure syndrome induced by chemicals such as busulfan and cyclophosphamide; and evaluating the treatment capacity of allogenous bone marrow transplantation on mouse models of BMF syndrome. The results showed that the combination of the two chemicals, the death rate caused by BMF can reach to 67%. The bone marrow transplantation can improve the alive ratio of mouse, which have bone marrow failure syndromes, from 33% to 88%.

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Issue: Vol 13 No 1 (2010)
Page No.: 5-15
Published: Mar 30, 2010
Section: Engineering and Technology - Research article

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Truong, N., Duong, T., Pham, P., & Phan, N. (2010). ALLOGENOUS BONE MARROW TRANSPLANTATION FOR BONE MARROW FAILURE SYNDROME ON MOUSE MODEL. Science and Technology Development Journal, 13(1), 5-15.

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