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Our preliminary screening study revealed that the methanolic extract of Stholobus parviflorus (Roxb.) exhibited potent a-glucosidase inhibitory activity with an IC50 value of 0.05 μg mL-1. Therefore, we carried out activity-guided fractionation of the MeOH extract and isolated three compounds. These compounds were determinated as ferulic acid (1), protocatechuic acid (2) and epicatechin (3) by analysis of spectroscopic data. The IC50 values of these compounds were 45.30, 23.04 and > 100 μM, respectively. Acid tannic was used as a positive control with an IC50 value of 0.91 nM.

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Issue: Vol 14 No 2 (2011)
Page No.: 43-49
Published: Jun 30, 2011
Section: Natural Sciences - Research article

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Copyright: The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 How to Cite
Nguyen, M., Phan, T., Nguyen, H., & Nguyen, N. (2011). a-GLUCOSIDASE INHIBITORY ACTIVITY AND CHEMICAL CONSTITUENTS OF Satholobus parviflorus (Roxb.). Science and Technology Development Journal, 14(2), 43-49.

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