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VNUHCM Journal of

Science and Technology Development

An official journal of Viet Nam National University Ho Chi Minh City, Viet Nam since 1997

ISSN: 1859-0128
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Natural Sciences - Research article Open Access Logo

a-GLUCOSIDASE INHIBITORY ACTIVITY AND CHEMICAL CONSTITUENTS OF Satholobus parviflorus (Roxb.)

Mai Thi Thanh Nguyen 1, *
Trong Nguyen Huu Phan 1
Hai Xuan Nguyen 1
Nhan Trung Nguyen 1

  1. University of Science, VNU-HCM
Correspondence to: Mai Thi Thanh Nguyen, University of Science, VNU-HCM. Email: pvphuc@hcmuns.edu.vn.
Volume & Issue: Vol. 14 No. 2 (2011) | Page No.: 43-49 | DOI: 10.32508/stdj.v14i2.1942
Published: 2011-06-30

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Copyright © 2011 by the author(s).

Copyright The Author(s) 2023. This article is published with open access by Vietnam National University, Ho Chi Minh city, Vietnam. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. 

Abstract

Our preliminary screening study revealed that the methanolic extract of Stholobus parviflorus (Roxb.) exhibited potent a-glucosidase inhibitory activity with an IC50 value of 0.05 μg mL-1. Therefore, we carried out activity-guided fractionation of the MeOH extract and isolated three compounds. These compounds were determinated as ferulic acid (1), protocatechuic acid (2) and epicatechin (3) by analysis of spectroscopic data. The IC50 values of these compounds were 45.30, 23.04 and > 100 μM, respectively. Acid tannic was used as a positive control with an IC50 value of 0.91 nM.

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