Anti-inflammatory effects of the bee venom in experimental arthritis rats

Abstract

Study on anti-inflammatory, pain reduction effects of bee venom have been executed by many scientists in the world. On the experimental animals, bee venom has shown anti-inflammatory capabilities and using bee venom in point accupunture got more efficiency than other methods. Our study conducted on 60 rats divided into 5 groups: control group, arthritis group (with complete adjuvant solution) plus saline treatment, arthritis group plus bee venom treatment (doses: 0.5 mg/kg, 1 mg/kg and 1.5 mg/kg) and arthritis group plus Mobic treatment (1 mg/kg), bee venom and Mobic were administered in zusalin acupuncture point in rat’s hind limb. Results showed: complete adjuvant solution (the only dose of 50 μL injected at rat’s hind limb) induced the joint inflammation, temperature increase, pain in rat’s hind limb, leukocytosis and erythrocyte reduction in peripheral blood. Bee venom (1 mg/kg and 1.5 mg/kg) induced the analgesic effect, temperature reduction in on rat’s hind limb and slight leukocytosis in peripheral blood in 21 days after adjuvant injection. The anti-inflamatory effect of bee venom (1.5 mg/kg) is similar to Mobic (1 mg/kg) on rats.